Selected Publications
[30] Kamieniarz-Gdula K, Gdula MR, Panser K, Nojima T, Monks J, Wiśniewski JR, Riepsaame J, Brockdorff N, Pauli A, Proudfoot NJ. (2019) Selective Roles of Vertebrate PCF11 in Premature and Full-Length Transcript Termination. Molecular Cell 74(1):158-172.
[29] Tan-Wong SM, Dhir S, Proudfoot NJ. (2019) R-Loops Promote Antisense Transcription across the Mammalian Genome. Molecular Cell 76(4):600-616.
[28] Nojima T, Tellier M, Foxwell J, Ribeiro de Almeida C, Tan-Wong SM, Dhir S, Dujardin G, Dhir A, Murphy S, Proudfoot NJ. (2018) Deregulated Expression of Mammalian lncRNA through Loss of SPT6 Induces R-Loop Formation, Replication Stress, and Cellular Senescence. Molecular Cell 72(6):970-984.
[27] Ribeiro de Almeida C, Dhir S, Dhir A, Moghaddam AE, Sattentau Q, Meinhart A, Proudfoot NJ. (2018) RNA Helicase DDX1 Converts RNA G-Quadruplex Structures into R-Loops to Promote IgH Class Switch Recombination. Molecular Cell 70(4):650-662.
[27] Schlackow M, Nojima T, Gomes T, Dhir A, Carmo-Fonseca M and Proudfoot NJ. (2017) Distinctive Patterns of Transcription and RNA Processing for Human lincRNAs. Molecular Cell 65(1): 25-38
[26] Nojima T, Rebelo K, Gomes T, Grosso AR, Proudfoot NJ, Carmo-Fonseca M. (2018) RNA Polymerase II Phosphorylated on CTD Serine 5 Interacts with the Spliceosome during Co-transcriptional Splicing. Molecular Cell 72(2):369-379.
[25] Nojima T, Gomes T, Grosso, ARF, Kimura H, Dye MJ, Dhir S, Carmo-Fonseca M, and Proudfoot NJ. (2015) Mammalian NET-seq reveals genome-wide nascent transcription coupled to RNA processing. Cell 161(3): 526-540.
[24] Dhir A, Dhir S, Proudfoot NJ, Jopling CL. (2015) Microprocessor mediates transcriptional termination of long noncoding RNA transcripts hosting microRNAs. Nature Structural and Molecular Biology 22(4): 319-27.
[23] Skourti-Stathaki K, Kamieniarz-Gdula K, Proudfoot NJ. (2014) R-loops induce repressive chromatin marks over mammalian gene terminators. Nature 516(7531): 436-9
[22] Tan-Wong SM, Zaugg JB, Camblong J, Xu J, Zhang DW, Mischo HE, Ansari AZ, Luscombe NM, Steinmetz LM, Proudfoot NJ. (2012) Gene loops enhance transcriptional directionality. Science 338(6107): 671-5.
[21] Skourti-Stathaki K, Proudfoot NJ, Gromak N. (2011) Human senataxin resolves RNA/DNA hybrids formed at transcriptional pause sites to promote Xrn2-dependent termination. Molecular Cell 42(6): 794-805.
[20] Mischo HE, Gómez-González B, Grzechnik P, Rondón AG, Wei W, Steinmetz L, Aguilera A, Proudfoot NJ. (2011) Yeast Sen1 helicase protects the genome from transcription-associated instability. Molecular Cell 41(1): 21-32.
[19] Morlando M, Ballarino M, Gromak N, Pagano F, Bozzoni I, Proudfoot NJ. (2008) Primary microRNA transcripts are processed co-transcriptionally. Nature Structural and Molecular Biology 15(9): 902-9.
[18] Gullerova M, Proudfoot NJ. (2008) Cohesin complex promotes transcriptional termination between convergent genes in S. pombe. Cell 132(6): 983-95.
[17] Kawauchi J, Mischo H, Braglia P, Rondon A, Proudfoot NJ. (2008) Budding yeast RNA polymerases I and II employ parallel mechanisms of transcriptional termination. Genes & Development 22(8): 1082-92.
[16] West S, Proudfoot NJ, Dye MJ. (2008) Molecular dissection of mammalian RNA polymerase II transcriptional termination. Molecular Cell 29(5): 600-10.
[15] West S, Gromak N and Proudfoot NJ. (2004) Human 5' --> 3' exonuclease Xrn2 promotes transcription termination at co-transcriptional cleavage sites. Nature 432(7016): 522-5
[14] O'Sullivan JM, Tan-Wong SM, Morillon A, Lee B, Coles J, Mellor J, Proudfoot NJ. (2004) Gene loops juxtapose promoters and terminators in yeast. Nature Genetics 36(9): 1014-8
[13] Prescott EM, Proudfoot NJ. (2002) Transcriptional collision between convergent genes in budding yeast. Proceedings of the National Academy of Sciences 99(13): 8796-801
[12] Barillà D, Lee BA, Proudfoot NJ. (2001) Cleavage/polyadenylation factor IA associates with the carboxyl-terminal domain of RNA polymerase II in Saccharomyces cerevisiae. Proceedings of the National Academy of Sciences 98(2): 445-50.
[11] Dye MJ, Proudfoot NJ. (2001) Multiple transcript cleavage precedes polymerase release in termination by RNA polymerase II. Cell 105(5): 669-81
[10] Greger IH, Aranda A, Proudfoot NJ. (2000) Balancing transcriptional interference and initiation on the GAL7 promoter of Saccharomyces cerevisiae. Proceedings of the National Academy of Sciences 97(15): 8415-20.
[9] Birse CE, Minvielle-Sebastia L, Lee BA, Keller W, Proudfoot NJ. (1998) Coupling termination of transcription to messenger RNA maturation in yeast. Science 80(5361): 298-301.
[8] Ashe HL, Monks J, Wijgerde M, Fraser P, Proudfoot NJ. (1997) Intergenic transcription and transinduction of the human beta-globin locus. Genes & Development11(19): 2494-509.
[7] Proudfoot NJ. (1986) Transcriptional interference and termination between duplicated alpha-globin gene constructs suggests a novel mechanism for gene regulation. Nature 322(6079): 562-5.
[6] Whitelaw E, Proudfoot NJ. (1986) Alpha-thalassaemia caused by a poly(A) site mutation reveals that transcriptional termination is linked to 3' end processing in the human alpha 2 globin gene. EMBO Journal 5(11): 2915-22.
[5] Higgs DR, Goodbourn SE, Lamb J, Clegg JB, Weatherall DJ, Proudfoot NJ. (1983) Alpha-thalassaemia caused by a polyadenylation signal mutation. Nature 306(5941): 398-400.
[4] Proudfoot NJ, Shander MH, Manley JL, Gefter ML, Maniatis T. (1980) Structure and in vitro transcription of human globin genes. Science 209(4463): 1329-36.
[3] Proudfoot NJ, Maniatis T. (1980) The structure of a human alpha-globin pseudogene and its relationship to alpha-globin gene duplication. Cell 21(2): 537-44.
[2] Proudfoot NJ, Baralle FE. (1979) Molecular cloning of human epsilon-globin gene. Proceedings of the National Academy of Sciences 76(11): 5435-9.
[1] Proudfoot NJ and Brownlee GG. (1976) 3' non-coding region sequences in eukaryotic messenger RNA. Nature 263(5574): 211-4.
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